Teenage superhero Gwen Stacy, a.k.a. Ghost-Spider, is used to spending her time fighting for justice and playing drums in her band. But when she finds herself accused of being on the wrong side of the law - chased by her police captain father, as well as a host of young heroes including Ms. Marvel, Squirrel Girl, Quake and Patriot - Ghost-Spider must go on the run to prove her innocence.