The twenty-first season of the American medical drama television series Grey’s Anatomy returns as the story deepens when the new doctors step into leadership. Emotional fallout from the past season lingers, and big decisions shape the future of Grey Sloan. As the aftermath of a convenience store shooting brings chaos to Grey Sloan, Ben hits a wall with his new emergency preparedness plan. Meredith and Nick will return to Grey Sloan to treat a liver transplant patient. Jo and Link struggle with wedding planning as the day arrives, along with some visitors. Legacy characters and fresh faces continue to balance life, loss, and medicine.