During his lifetime, Vincent Van Gogh has no greater champion of his work than his devoted brother, Theo. As an art gallery owner, Theo pushes for the recognition that Van Gogh’s masterpieces deserve, only to meet with abject failure. While Van Gogh struggles with obscurity and mental illness, Theo faces serious financial difficulties due to poor sales. Eventually, both the Van Gogh brothers begin falling apart over the reality of their unrealized dreams.